New approaches to particle induced prompt gamma imaging

TL;DR

This paper presents innovative methods for prompt gamma imaging induced by protons, including collimator-based range verification, fiducial marker identification, and high-resolution 3D imaging, supported by simulations and experimental tests.

Contribution

It introduces three novel approaches for prompt gamma imaging, enhancing proton range verification and target characterization in medical applications.

Findings

Range verification accuracy of 0.7 mm near tumor regions

Identification of 984 keV prompt gamma from fiducial markers

Achieved spatial resolution of 2.6 mm with high detection efficiency

Abstract

The distribution of the prompt gamma emissions induced by proton interactions in a target material carries information concerning the proton range and target composition. In order to image prompt gamma we present different approaches. The first approach is based on knife-edge collimator utilized in tandem with a compact PET type detector in order to verify proton range by measuring the depth distribution of prompt gamma relying on Compton scattered events. A second approach aims at unambiguously identifying the presence of protons in a region of interest by introducing a bio-compatible fiducial marker in the patient and measuring the characteristic prompt gamma of the marker against background material. A third approach illustrates a novel design for position sensitive gamma imaging with a millimeter level adjustable position resolution with a high detection efficiency which is a step towards 3D prompt gamma imaging, useful to better understand the target composition. Simulations of the designs were performed using GATE/Geant4 Monte Carlo framework. Experimental tests on fiducial marker were conducted at the proton facilities in INER and Chang Gung Memorial hospital. Using the knife-edge PET approach a range verification of 0.7 mm can be achieved for shifts within 1 cm near the tumor region and up to 4 mm for shifts within a 4 cm window. For the fiducial marker approach we identify 984 keV as the dominant prompt gamma and show that for the 50% relative PG intensity, the R80 position falls within a 3 mm thick 48Ti marker. Using the position sensitive gamma imaging approach we present a feasible design to achieve spatial resolution values of 2.6 mm with a detection efficiency of 5.4E-6 at 6.1 MeV and up to eight depth positions in a single run. The relative advantage of these methods and the challenges in the implementation are discussed.