Intracranial EEG structure-function coupling predicts surgical outcomes in focal epilepsy

TL;DR

This study shows that preoperative intracranial EEG-based structure-function coupling can predict surgical outcomes in focal epilepsy, with stronger coupling indicating a higher likelihood of seizure freedom post-surgery.

Contribution

It introduces a novel approach combining intracranial EEG and imaging data to assess structure-function coupling as a predictor of surgical success in epilepsy.

Findings

Stronger preoperative structure-function coupling correlates with seizure freedom.

Structure-function coupling predicts surgical outcomes with 85% accuracy.

Virtual surgeries help localize epileptogenic tissue and inform surgical planning.

Abstract

Alterations to structural and functional brain networks have been reported across many neurological conditions. However, the relationship between structure and function -- their coupling -- is relatively unexplored, particularly in the context of an intervention. Epilepsy surgery alters the brain structure and networks to control the functional abnormality of seizures. Given that surgery is a structural modification aiming to alter the function, we hypothesized that stronger structure-function coupling preoperatively is associated with a greater chance of post-operative seizure control. We constructed structural and functional brain networks in 39 subjects with medication-resistant focal epilepsy using data from intracranial EEG (pre-surgery), structural MRI (pre-and post-surgery), and diffusion MRI (pre-surgery). We investigated pre-operative structure-function coupling at two spatial scales a) at the global iEEG network level and b) at the resolution of individual iEEG electrode contacts using virtual surgeries. At global network level, seizure-free individuals had stronger structure-function coupling pre-operatively than those that were not seizure-free regardless of the choice of interictal segment or frequency band. At the resolution of individual iEEG contacts, the virtual surgery approach provided complementary information to localize epileptogenic tissues. In predicting seizure outcomes, structure-function coupling measures were more important than clinical attributes, and together they predicted seizure outcomes with an accuracy of 85% and sensitivity of 87%. The underlying assumption that the structural changes induced by surgery translate to the functional level to control seizures is valid when the structure-functional coupling is strong. Mapping the regions that contribute to structure-functional coupling using virtual surgeries may help aid surgical planning.