Solid-state heteronuclear multiple-quantum spectroscopy under a magic-angle spinning frequency of 150 kHz

TL;DR

This paper demonstrates the feasibility of 1H detected 15N-1H heteronuclear multiple-quantum spectroscopy at a high magic-angle spinning frequency of 150 kHz, enhancing solid-state NMR techniques.

Contribution

It introduces a method to perform heteronuclear multiple-quantum spectroscopy at 150 kHz MAS, with improved acquisition strategies for chemical shift evolution.

Findings

Successful implementation at 150 kHz MAS

Direct excitation of heteronuclear multiple-quantum coherences

Heteronuclear correlation spectrum obtained by shearing

Abstract

We hereby demonstrate that 1H detected 15N-1H heteronuclear multiple-quantum spectroscopy can be carried out at a magic angle spinning frequency of 150 kHz. While the 15N-1H multiple-quantum coherences can be directly excited from the dipolar order created by the method of adiabatic demagnetization in the rotating frame, it is technically more advantageous to acquire the chemical shift evolution of the heteronuclear multiple-quantum coherence by two separate chemical shift evolution periods for 1H and 15N. We also show that the heteronuclear multiple-quantum correlation spectrum can be obtained by shearing the corresponding heteronuclear single-quantum correlation spectrum.