Robust Fingerprinting of Genomic Databases

TL;DR

This paper introduces a robust fingerprinting scheme for genomic databases that withstands correlation attacks, ensuring data source accountability while maintaining database utility.

Contribution

It develops a novel fingerprinting method tailored for genomic data and proposes mitigation techniques to resist correlation attacks, filling a key gap in data security.

Findings

Correlation attacks can distort over half of fingerprint bits with minimal utility loss.

Proposed mitigation techniques significantly reduce attacker's ability to compromise fingerprint bits.

The scheme maintains database utility despite robust attack resistance.

Abstract

Database fingerprinting has been widely used to discourage unauthorized redistribution of data by providing means to identify the source of data leakages. However, there is no fingerprinting scheme aiming at achieving liability guarantees when sharing genomic databases. Thus, we are motivated to fill in this gap by devising a vanilla fingerprinting scheme specifically for genomic databases. Moreover, since malicious genomic database recipients may compromise the embedded fingerprint by launching effective correlation attacks which leverage the intrinsic correlations among genomic data (e.g., Mendel's law and linkage disequilibrium), we also augment the vanilla scheme by developing mitigation techniques to achieve robust fingerprinting of genomic databases against correlation attacks. We first show that correlation attacks against fingerprinting schemes for genomic databases are very powerful. In particular, the correlation attacks can distort more than half of the fingerprint bits by causing a small utility loss (e.g.,database accuracy and consistency of SNP-phenotype associations measured via p-values). Next, we experimentally show that the correlation attacks can be effectively mitigated by our proposed mitigation techniques. We validate that the attacker can hardly compromise a large portion of the fingerprint bits even if it pays a higher cost in terms of degradation of the database utility. For example, with around 24% loss in accuracy and 20% loss in the consistency of SNP-phenotype associations, the attacker can only distort about 30% fingerprint bits, which is insufficient for it to avoid being accused. We also show that the proposed mitigation techniques also preserve the utility of the shared genomic databases.