Local accumulation times in a diffusion-trapping model of synaptic receptor dynamics

TL;DR

This paper introduces a new method to analyze the transient dynamics of synaptic receptor distribution using local accumulation times, revealing insights into heterosynaptic plasticity and synaptic weight distribution.

Contribution

The paper presents a novel approach for calculating local accumulation times in a diffusion-trapping model of receptor dynamics, highlighting the spatial dependence of transient synaptic changes.

Findings

Local accumulation times depend on the number and location of synapses.

Steady-state synaptic weights are independent of each other under slow exocytosis/endocytosis.

Local accumulation times can inform about synaptic weight distribution.

Abstract

The lateral diffusion and trapping of neurotransmitter receptors within the postsynaptic membrane of a neuron plays a key role in determining synaptic strength and plasticity. Trapping is mediated by the reversible binding of receptors to scaffolding proteins (slots) within a synapse. In this paper we introduce a new method for analyzing the transient dynamics of synapses in a diffusion-trapping model of receptor trafficking. Given a population of spatially distributed synapses, each of which has a fixed number of slots, we calculate the rate of relaxation to the steady-state distribution of bound slots (synaptic weights) in terms of a set of local accumulation times. Assuming that the rates of exocytosis and endocytosis are sufficiently slow, we show that the steady-state synaptic weights are independent of each other (purely local). On the other hand, the local accumulation time of a given synapse depends on the number of slots and the spatial location of all the synapses, indicating a form of transient heterosynaptic plasticity. This suggests that local accumulation time measurements could provide useful information regarding the distribution of synaptic weights within a dendrite.