Point Spread Function Estimation of Defocus
Renzhi He, Yan Zhuang, Boya Fu, Fei Liu

TL;DR
This paper introduces a novel method for accurately estimating the point spread function (PSF) of defocus in computational imaging, improving the modeling of the defocus process for applications like depth estimation and microscopy.
Contribution
We develop an algorithm to precisely model the defocus PSF by combining simulated and real images with a novel histogram-based similarity metric.
Findings
Our algorithm accurately describes the defocus PSF.
The proposed method reduces the loss by 40% compared to existing approaches.
Experiments validate the effectiveness of the PSF estimation in real-world scenarios.
Abstract
This Point spread function (PSF) plays a crucial role in many computational imaging applications, such as shape from focus/defocus, depth estimation, and fluorescence microscopy. However, the mathematical model of the defocus process is still unclear. In this work, we develop an alternative method to estimate the precise mathematical model of the point spread function to describe the defocus process. We first derive the mathematical algorithm for the PSF which is used to generate the simulated focused images for different focus depth. Then we compute the loss function of the similarity between the simulated focused images and real focused images where we design a novel and efficient metric based on the defocus histogram to evaluate the difference between the focused images. After we solve the minimum value of the loss function, it means we find the optimal parameters for the PSF. We…
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Taxonomy
TopicsImage Processing Techniques and Applications · Advanced Fluorescence Microscopy Techniques · Immunotherapy and Immune Responses
