A mathematical study of the role of tBregs in breast cancer

TL;DR

This paper presents a mathematical model analyzing how regulatory B cells (tBregs) influence breast cancer progression, combining analytical and numerical methods to understand their role in tumor immune response.

Contribution

It introduces a simplified mathematical model specifically focusing on tBregs' impact on breast cancer, providing new insights into their dynamical role in tumor promotion.

Findings

tBregs significantly promote tumor growth in the model

Analytical and numerical analysis reveals key dynamics of immune response

Model offers a framework for future therapeutic strategies

Abstract

A model for the mathematical study of immune response to breast cancer is proposed and studied, both analytically and numerically. It is a simplification of a complex one, recently introduced by two of the present authors. It serves for a compact study of the dynamical role in cancer promotion of a relatively recently described subgroup of regulatory B cells, which are evoked by the tumour.