Pulse-echo speed-of-sound imaging using convex probes

TL;DR

This paper adapts computed ultrasound tomography in echo mode (CUTE) for convex probes to enable deeper and wider-area liver imaging, demonstrating feasibility in phantoms and preliminary in vivo results, with challenges in deep tissue quantification.

Contribution

It introduces a novel adaptation of CUTE for convex probes, optimizing computational efficiency for liver imaging applications.

Findings

Accurate quantitative SoS is feasible with convex probes in phantoms.

Preliminary in vivo results confirm potential for liver imaging.

Deep tissue imaging remains challenging due to tissue complexity.

Abstract

Computed ultrasound tomography in echo mode (CUTE) is a new ultrasound (US)-based medical imaging modality with promise for diagnosing various types of disease based on the tissue's speed of sound (SoS). It is developed for conventional pulse-echo US using handheld probes and can thus be implemented in state-of-the-art medical US systems. One promising application is the quantification of the liver fat fraction in fatty liver disease. So far, CUTE was demonstrated using linear array probes where the imaging depth is comparable to the aperture size. For liver imaging, however, convex probes are preferred since they provide a larger penetration depth and a wider view angle allowing to capture a large area of the liver. With the goal of liver imaging in mind, we adapt CUTE to convex probes, with a special focus on discussing strategies that make use of the convex geometry in order to make our implementation computationally efficient. We then demonstrate in an abdominal imaging phantom that accurate quantitative SoS using convex probes is feasible, in spite of the smaller aperture size in relation to the image area compared to linear arrays. A preliminary in vivo result of liver imaging confirms this outcome, but also indicates that deep quantitative imaging in the real liver can be more challenging, probably due to the increased complexity of the tissue compared to phantoms.