Non-invasive chemically selective energy delivery and focusing inside a scattering medium guided by Raman scattering

TL;DR

This paper introduces a method for chemically selective energy delivery inside scattering media by using Raman scattering and wavefront shaping, achieving significant signal enhancement and targeted focusing on Raman-active particles.

Contribution

It presents a novel technique combining spectral Raman information with wavefront shaping for non-invasive, chemically selective energy focusing in scattering environments.

Findings

Six-fold enhancement in Raman signal

Targeted energy deposition on specific particles

Effective wavefront shaping guided by Raman feedback

Abstract

Raman scattering is a chemically selective probing mechanism with diverse applications in industry and clinical settings. Yet, most samples are optically opaque limiting the applicability of Raman probing at depth. Here, we demonstrate chemically selective energy deposition behind a scattering medium by combining prior information on the chemical's spectrum with the measurement of a spectrally resolved Raman speckle as a feedback mechanism for wavefront shaping. We demonstrate unprecedented six-fold signal enhancement in an epi-geometry, realizing targeted energy deposition and focusing on selected Raman active particles.