Functional Optical Coherence Tomography for Intrinsic Signal Optoretinography: Recent Developments and Deployment Challenges

TL;DR

This paper reviews recent advances in functional optical coherence tomography (OCT) for intrinsic signal optoretinography (ORG), highlighting technical challenges and perspectives for clinical deployment of noninvasive retinal function assessment.

Contribution

It summarizes recent developments in functional OCT for ORG, including IOS processing methods and discusses challenges for standardization and quantitative analysis.

Findings

Recent OCT-based IOS processing techniques

Identification of sources and mechanisms of IOS

Discussion of technical and deployment challenges

Abstract

Intrinsic optical signal (IOS) imaging of the retina, also termed as optoretinography (ORG), promises a noninvasive method for objective assessment of retinal function. By providing unparalleled capability to differentiate individual layers of the retina, functional optical coherence tomography (OCT) has been actively investigated for intrinsic signal ORG measurements. However, clinical deployment of functional OCT for quantitative ORG is still challenging due to the lack of a standardized imaging protocol and the complication of IOS sources and mechanisms. This article aims to summarize recent developments of functional OCT for ORG measurement, OCT intensity- and phase-based IOS processing. Technical challenges and perspectives of quantitative IOS analysis and ORG interpretations are discussed.