Thermodynamics of chromosome inversions and 100 million years of Lachancea evolution

TL;DR

This paper models chromosome inversions in evolving populations using thermodynamic principles, linking biochemical mutation processes to energy concepts, and compares the model to observed data in Lachancea yeast.

Contribution

It introduces a thermodynamic model of chromosome inversions, connecting mutation rates to energy barriers and applying it to yeast evolution data.

Findings

Model aligns with observed inversion distributions

Energy barriers influence mutation dynamics

Thermodynamic parameters relate to mutation rates

Abstract

Gene sequences of a deme evolve over time as new chromosome inversions appear in a population via mutations, some of which will replace an existing sequence. The underlying biochemical processes that generates these and other mutations are governed by the laws of thermodynamics, although the connection between thermodynamics and the generation and propagation of mutations are often neglected. Here, chromosome inversions are modeled as a specific example of mutations in an evolving system. The thermodynamic concepts of chemical potential, energy, and temperature are linked to the input parameters that include inversion rate, recombination loss rate and deme size. An energy barrier to existing gene sequence replacement is a natural consequence of the model. Finally, the model calculations are compared to the observed chromosome inversion distribution of the Lachancea genus of yeast. The model introduced in this work should be applicable to other types of mutations in evolving systems.