Simulations of surface charge density changes during the untreated solid tumor growth

TL;DR

This study models how surface charge density at tumor boundaries changes during untreated tumor growth, linking electrical properties to tumor progression and potential therapeutic strategies.

Contribution

It introduces an analytical model using Gompertz and Poisson equations to simulate surface charge density dynamics during tumor growth.

Findings

Surface charge density changes correlate with tumor growth stages

Electrical parameters relate to tumor progression and immune response

Modeling can inform chemotherapy and immunotherapy design

Abstract

Understanding the untreated tumor growth kinetics and its intrinsic findings is interesting and intriguing. The aim of this study is to propose an approximate analytical expression that allows to simulate changes in surface charge density changes at cancer-surrounding healthy tissue interface during the untreated solid tumor growth. For this, the Gompertz and Poisson equations are used. Simulations reveal that the unperturbed solid tumor growth is closely related to changes in the surface charge density over time between the tumor and the surrounding healthy tissue. Furthermore, the unperturbed solid tumor growth is governed by temporal changes in this surface charge density. It is concluded that graphic strategies corroborate the correspondence between the electrical and physiological parameters in the untreated cancer, which may have an essential role in its growth, progression, metastasis and protection against immune system attack and anti-cancer therapies. In addition, the knowledge of surface charge density changes at cancer-surrounding healthy tissue interface may be relevant when redesigning the molecules in chemotherapy and immunotherapy taking into account their polarities. This can also be true in the design of completely novel therapies.