Bone tumor suppression in rabbits by hyperthermia below the clinical safety limit using aligned magnetic bone cement

TL;DR

This study develops a magnetic bone cement with aligned nanoparticles that achieves efficient hyperthermia below safety limits, effectively suppressing bone tumors in rabbits and improving survival rates.

Contribution

The paper introduces a novel aligned magnetic bone cement with significantly enhanced heating efficiency under safe clinical parameters for tumor hyperthermia.

Findings

Achieved 30°C temperature increase in 180s at safe AC field levels.

50-fold increase in loss power compared to random nanoparticle orientation.

Effective tumor suppression and increased survival in rabbit model.

Abstract

Demonstrating highly efficient alternating current (AC) magnetic field heating of nanoparticles in physiological environments under clinically safe field parameters has remained a great challenge, hindering clinical applications of magnetic hyperthermia. In this work, we report exceptionally high loss power of magnetic bone cement under clinical safety limit of AC field parameters, incorporating DC field-aligned soft magnetic Zn0.3Fe2.7O4 nanoparticles with low concentration. Under an AC field of 4 kA/m at 430 kHz, the aligned bone cement with 0.2 wt% nanoparticles achieved a temperature increase of 30 C in 180 s. This amounts to a specific loss power value of 327 W/gmetal and an intrinsic loss power of 47 nHm^2/kg, which is enhanced by 50-fold compared to randomly oriented samples. The high-performance magnetic bone cement allows for the demonstration of effective hyperthermia suppression of tumor growth in the bone marrow cavity of New Zealand White Rabbits subjecting to rapid cooling due to blood circulation, and significant enhancement of survival rate.