Persistence and stability of a class of kinetic compartmental models

TL;DR

This paper proves the persistence and stability of a class of kinetic compartmental models with bounded capacities and monotone reaction rates, using chemical reaction network theory and Petri net analysis.

Contribution

It introduces a novel approach to analyze persistence and stability in kinetic compartmental models via Petri nets and siphon characterization.

Findings

All siphons in the Petri net can be efficiently characterized.

Existence and stability of equilibria are established.

Results apply to models based on the simple exclusion principle.

Abstract

In this paper we show that the dynamics of a class of kinetic compartmental models with bounded capacities, monotone reaction rates and a strongly connected interconnection structure is persistent. The result is based on the chemical reaction network (CRN) and the corresponding Petri net representation of the system. For the persistence analysis, it is shown that all siphons in the Petri net of the studied model class can be characterized efficiently. Additionally, the existence and stability of equilibria are also analyzed building on the persistence and the theory of general compartmental systems. The obtained results can be applied in the analysis of general kinetic models based on the simple exclusion principle.