DNA Base Detection Using Two-Dimensional Materials Beyond Graphene

TL;DR

This paper reviews the advancements and potential of various two-dimensional materials beyond graphene for DNA base detection, emphasizing their superior properties and future opportunities in nanopore sequencing.

Contribution

It provides a comprehensive overview of non-graphene 2D materials for DNA sequencing, highlighting recent progress, challenges, and future prospects in the field.

Findings

Graphene has demonstrated potential for nanopore DNA sequencing.

Other 2D materials like boron nitride and transition metal dichalcogenides show promise.

Challenges remain in achieving single-base resolution with these materials.

Abstract

The success of graphene for nanopore DNA sequencing has shown that it is possible to explore other potential single- and few-atom thick layers of 2D materials beyond graphene, and also that these materials can exhibit fascinating and technologically useful properties for DNA base detection that are superior to those of graphene. In this article, we review the state-of-the art of DNA base detection using 2D materials beyond graphene. Initially, we present an overview of nanopore-based DNA sequencing methods using biological and solid-state nanopores, and discuss several challenges that limit their use for single-base resolution. Then we outline the progress, challenges, and opportunities using graphene. Additionally, we discuss several potential 2D materials beyond graphene such as hexagonal boron nitride, elemental 2D materials beyond graphene, and 2D transition metal dichalcogenides. Finally, we highlight the potential of using van der Waals materials for advanced DNA base detection technologies.