Un nouvel algorithme pour la detection des transferts horizontaux de genes partiels entre les especes et pour la classification des transferts inferes

TL;DR

This paper introduces a novel algorithm that detects and validates partial horizontal gene transfers in genomes using a sliding window and bootstrap support, also capable of confirming complete HGT events.

Contribution

The paper presents a new algorithm for identifying partial and complete HGT events, enhancing genome mosaicism analysis and evolutionary studies.

Findings

Effective detection of partial HGT events in genome sequences

Bootstrap support provides confidence levels for inferred transfers

Applicable to full-genome analysis of mosaicism and HGT rates

Abstract

In this article we are describing a new algorithm for detecting and validating partial horizontal gene transfers (HGT). The presented algorithm is based on a sliding window procedure which analyzes fragments of the given multiple sequence alignment. A bootstrap procedure incorporated in our method can be used to estimate the support of each inferred partial HGT. The new algorithm can be also applied to confirm or discard complete (i.e., traditional) horizontal gene transfers detected by any HGT inferring algorithm. While working on a full-genome scale, the introduced algorithm can be used to assess the level of mosaicism of the whole species genomes as well as the rates of complete and partial HGT underlying the evolution of the considered set of species.