Polarised superlocalization in magnetic nanoparticle hyperthermia

TL;DR

This paper investigates how static and alternating magnetic fields can be combined to enhance the local heating effect of magnetic nanoparticles in hyperthermia therapy, focusing on the polarization effects at different frequencies and field strengths.

Contribution

It provides a theoretical and experimental comparison of perpendicular versus parallel field configurations for improved superlocalization in magnetic hyperthermia.

Findings

Polarization effects are significant at small frequencies and large field strengths.

Superlocalization is maximized when the static and oscillating fields are configured optimally.

Experimental results confirm the theoretical predictions of enhanced localization.

Abstract

Magnetic hyperthermia is an adjuvant therapy for cancer where injected magnetic nanoparticles are used to transfer energy from the time-dependent applied magnetic field into the surrounding medium. Its main importance is to be able to increase the temperature of the human body locally. This localization can be further increased by using a combination of static and alternating external magnetic fields. For example, if the static field is inhomogeneous and the alternating field is oscillating then the energy transfer and consequently, the heat generation is non-vanishing only where the gradient field is zero which results in superlocalization. Our goal here is to study theoretically and experimentally whether the perpendicular or parallel combination of static and oscillating fields produce a better superlocalization. A considerable polarisation effect in superlocalization for small frequencies and large field strengths which are of great importance in practice is found.