Sensitive label-free IgG detection using MEMS QCM biosensor with 125-MHz wireless quartz resonator

TL;DR

This paper introduces a compact, wireless MEMS QCM biosensor with a 125-MHz quartz resonator capable of sensitive, label-free IgG detection at low concentrations, outperforming traditional methods like SPR.

Contribution

The study presents a novel MEMS-based wireless QCM biosensor with high sensitivity and low detection limit, suitable for mass production and miniaturization.

Findings

Detection limit of 1 ng/mL or less

Good agreement with known binding affinity values

Advantages include low cost, low power, and high reliability

Abstract

We present a wireless QCM biosensor fabricated using MEMS technology. The MEMS QCM biosensor contains a 125-MHz AT-cut quartz resonator embedded in the microchannel. Because of the compact design, the MEMS QCM biosensor is suitable for mass production and device miniaturization. We performed the IgG detection measurement with different concentrations. The detection limit was l ng/mL or less, which is superior to that of the gold-standard SPR method. Furthermore, we studied the binding affinity between protein A and IgG by studying the frequency response of the QCM biosensor. It shows good agreement with reported values. Therefore, the presented MEMS QCM biosensor has advantages of compact, low cost, low power consumption, high sensitivity, and reliability.