Overcoming the Domain Gap in Contrastive Learning of Neural Action Representations

TL;DR

This paper introduces a new multimodal dataset of fruit fly neural and behavioral data and proposes augmentation techniques to improve contrastive learning of neural action representations across different animals.

Contribution

The paper presents a novel dataset and effective augmentation methods that address inter-animal variability in neural and behavioral data for contrastive learning.

Findings

Augmentations significantly reduce inter-animal domain gap

Contrastive learning improves neural action representations

Dataset enables better neural-behavioral understanding

Abstract

A fundamental goal in neuroscience is to understand the relationship between neural activity and behavior. For example, the ability to extract behavioral intentions from neural data, or neural decoding, is critical for developing effective brain machine interfaces. Although simple linear models have been applied to this challenge, they cannot identify important non-linear relationships. Thus, a self-supervised means of identifying non-linear relationships between neural dynamics and behavior, in order to compute neural representations, remains an important open problem. To address this challenge, we generated a new multimodal dataset consisting of the spontaneous behaviors generated by fruit flies, Drosophila melanogaster -- a popular model organism in neuroscience research. The dataset includes 3D markerless motion capture data from six camera views of the animal generating spontaneous actions, as well as synchronously acquired two-photon microscope images capturing the activity of descending neuron populations that are thought to drive actions. Standard contrastive learning and unsupervised domain adaptation techniques struggle to learn neural action representations (embeddings computed from the neural data describing action labels) due to large inter-animal differences in both neural and behavioral modalities. To overcome this deficiency, we developed simple yet effective augmentations that close the inter-animal domain gap, allowing us to extract behaviorally relevant, yet domain agnostic, information from neural data. This multimodal dataset and our new set of augmentations promise to accelerate the application of self-supervised learning methods in neuroscience.