Bridging scales in a multiscale pattern-forming system

TL;DR

This paper introduces a semi-phenomenological multiscale approach for analyzing pattern formation in biological systems, effectively linking large-scale dynamics to small-scale patterns through local dispersion relations and conservation laws.

Contribution

It presents a novel coarse-graining method that reconstructs small-scale pattern information from large-scale dynamics in mass-conserving reaction-diffusion systems.

Findings

Multiscale patterns observed in the Min system both in simulations and experiments.

Large-scale protein densities reliably predict pattern-forming dynamics.

The approach is versatile and applicable to various conservation-law-based systems.

Abstract

Self-organized pattern formation is vital for many biological processes. Reaction-diffusion models have advanced our understanding of how biological systems develop spatial structures, starting from homogeneity. However, biological processes inherently involve multiple spatial and temporal scales and transition from one pattern to another over time, rather than progressing from homogeneity to a pattern. To deal with such multiscale systems, coarse-graining methods are needed that allow the dynamics to be reduced to the relevant degrees of freedom at large scales, but without losing information about the patterns at the small scales. Here, we present a semi-phenomenological approach which exploits mass-conservation in pattern formation, and enables to reconstruct information about patterns from the large-scale dynamics. The basic idea is to partition the domain into distinct regions (coarse-grain) and determine instantaneous dispersion relations in each region, which ultimately inform about local pattern-forming instabilities. We illustrate our approach by studying the Min system, a paradigmatic model for protein pattern formation. By performing simulations, we first show that the Min system produces multiscale patterns in a spatially heterogeneous geometry. This prediction is confirmed experimentally by in vitro reconstitution of the Min system. Using a recently developed theoretical framework for mass-conserving reaction-diffusion systems, we show that the spatiotemporal evolution of the total protein densities on large-scales reliably predicts the pattern-forming dynamics. Our approach provides an alternative and versatile theoretical framework for complex systems where analytical coarse-graining methods are not applicable, and can in principle be applied to a wide range of systems with an underlying conservation law.