Is the kinetic resonance in human glucokinase genuine?

TL;DR

This paper critically examines the claim of kinetic resonance in human glucokinase, suggesting that previous explanations may be coincidental rather than indicative of a true physical mechanism.

Contribution

It provides a detailed analysis showing that the proposed kinetic resonance effect is likely a coincidence, challenging prior interpretations of glucokinase cooperativity.

Findings

Kinetic resonance may not be a genuine physical mechanism

Previous models might overinterpret coincidental effects

Reassessment of glucokinase's conformational regulation

Abstract

In the recent paper by Mu et al (J. Phys. Chem. Lett. 2021, 12, 2900) the maximal cooperativity of human glucokinase is explained by the "kinetic resonance" effect derived from a minimal three-state model. However, a closer inspection of the latter shows that this effect seems to be rather a particular quantitative coincidence than a general phenomenon that reflects a physical mechanism of conformational regulation.