Global analysis of a spatiotemporal cellular model for the transmission of hepatitis C virus with Hattaf-Yousfi functional response

TL;DR

This paper presents a comprehensive mathematical analysis of a spatiotemporal model for hepatitis C virus transmission, demonstrating conditions for disease clearance or persistence through stability analysis and numerical simulations.

Contribution

It introduces a global analysis of a PDE-based HCV model considering diffusion and therapy, establishing stability conditions for infection outcomes.

Findings

Uninfected equilibrium is globally stable if R0 ≤ 1, leading to disease clearance.

Infected equilibrium is globally stable if R0 > 1, indicating chronic infection.

Numerical simulations support the theoretical stability results.

Abstract

In this paper, a mathematical analysis of the global dynamics of a partial differential equation viral infection cellular model is carried out. We study the dynamics of a hepatitis C virus (HCV) model, under therapy, that considers both absorption phenomenon and diffusion of virions, infected and uninfected cells in liver. Firstly, we prove boundedness of the potential solutions, global existence, uniqueness and positivity of the solutions to the obtained initial value and boundary problem. Then, the dynamical behavior of the model is completely determined by a threshold parameter called the basic reproduction number $\mathcal{R}_{0}$. We show that the uninfected spatially homogeneous equilibrium of the model is globally asymptotically stable if $\mathcal{R}_{0} \leq 1 $ by using the direct Lyapunov method. This means that the HCV is cleared and the disease dies out. Also, the global asymptotically properties stability of the infected spatially homogeneous equilibrium of the model are studied via a skilful construction of a suitable Lyapunov functional. It means that the HCV persists in the host and the infection becomes chronic. Finally, numerical simulations are performed to support the theoretical results obtained.