Viscoelasticity and cell swirling motion

TL;DR

This paper reviews how viscoelastic properties of multicellular systems influence cell swirling motion during collective migration, highlighting the roles of residual stresses and rheological dynamics in instabilities relevant to biological processes.

Contribution

It emphasizes the impact of cell residual stresses and rheology on swirling motion, proposing a theoretical framework for understanding these instabilities in multicellular systems.

Findings

Residual stress distribution influences swirling motion

Viscoelastic forces can suppress collective migration

Surface tension and traction forces contribute to swirling patterns

Abstract

Although collective cell migration (CCM) is a highly coordinated and fine-tuned migratory mode, instabilities in the form of cell swirling motion (CSM) often occur. The CSM represents a product of the active turbulence obtained at low Reynolds number which has a feedback impact to various processes such as morphogenesis, wound healing, and cancer invasion. The cause of this phenomenon is related to the viscoelasticity of multicellular systems in the context of cell residual stress accumulation. Particular interest of this work is to: (1) emphasize the roles of cell shear and normal residual stress accumulated during CCM in the appearance of CSM and (2) consider the dynamics of CSM from the standpoint of rheology. Inhomogeneous distribution of the cell residual stress leads to a generation the viscoelastic force which acts to suppress CCM and can induces the system rapid stiffening. This force together with the surface tension force and traction force is responsible for the appearance of the CSM. In this work, a review of existing literature about viscoelasticity caused by CCM is given along with assortment of published experimental findings, in order to invite experimentalists to test given theoretical considerations in multicellular systems.