Approximating LCS and Alignment Distance over Multiple Sequences

TL;DR

This paper develops approximation algorithms for the complex problem of multiple sequence alignment, specifically for the longest common subsequence and alignment distance, achieving near-optimal results within feasible computational times.

Contribution

It introduces new approximation algorithms for LCS and AD of multiple sequences, improving runtime and approximation factors under certain conditions.

Findings

Approximate LCS within a factor of rac{ ext{lambda}^2 n}{2+ ext{epsilon}} in ilde{O}_m(n^{loor{rac{m}{2} floor+1}) time.

Approximate AD within a factor of 2 in ilde{O}_m(n^{ ext{ceil}rac{m}{2} floor}) time.

Below-2 approximation for AD achieved under specific pseudorandomness conditions.

Abstract

We study the problem of aligning multiple sequences with the goal of finding an alignment that either maximizes the number of aligned symbols (the longest common subsequence (LCS)), or minimizes the number of unaligned symbols (the alignment distance (AD)). Multiple sequence alignment is a well-studied problem in bioinformatics and is used to identify regions of similarity among DNA, RNA, or protein sequences to detect functional, structural, or evolutionary relationships among them. It is known that exact computation of LCS or AD of $m$ sequences each of length $n$ requires $\Theta(n^m)$ time unless the Strong Exponential Time Hypothesis is false. In this paper, we provide several results to approximate LCS and AD of multiple sequences. If the LCS of $m$ sequences each of length $n$ is $\lambda n$ for some $\lambda \in [0,1]$, then in $\tilde{O}_m(n^{\lfloor\frac{m}{2}\rfloor+1})$ time, we can return a common subsequence of length at least $\frac{\lambda^2 n}{2+\epsilon}$ for any arbitrary constant $\epsilon >0$. It is possible to approximate the AD within a factor of two in time $\tilde{O}_m(n^{\lceil\frac{m}{2}\rceil})$. However, going below-2 approximation requires breaking the triangle inequality barrier which is a major challenge in this area. No such algorithm with a running time of $O(n^{\alpha m})$ for any $\alpha < 1$ is known. If the AD is $\theta n$, then we design an algorithm that approximates the AD within an approximation factor of $\left(2-\frac{3\theta}{16}+\epsilon\right)$ in $\tilde{O}_m(n^{\lfloor\frac{m}{2}\rfloor+2})$ time. Thus, if $\theta$ is a constant, we get a below-two approximation in $\tilde{O}_m(n^{\lfloor\frac{m}{2}\rfloor+2})$ time. Moreover, we show if just one out of $m$ sequences is $(p,B)$-pseudorandom then, we get a below-2 approximation in $\tilde{O}_m(nB^{m-1}+n^{\lfloor \frac{m}{2}\rfloor+3})$ time irrespective of $\theta$.