Optimal Needle Placement for Prostate Rotating-Shield Brachytherapy (RSBT)

TL;DR

This paper introduces NEEPO, an optimization algorithm that enhances prostate RSBT by reducing needle count while maintaining dosimetric benefits, leading to more efficient and effective brachytherapy treatments.

Contribution

The work presents a novel convex optimization-based algorithm, NEEPO, that optimizes needle placement in prostate RSBT, reducing needle number without sacrificing treatment quality.

Findings

NEEPO effectively reduces needle count compared to baseline plans.

RSBT with NEEPO maintains improved dosimetry for urethra sparing and dose escalation.

Treatment plans with NEEPO show comparable or better dosimetric outcomes.

Abstract

Purpose: To present an efficient NEEdle Position Optimization (NEEPO) algorithm for prostate rotating shield brachytherapy (RSBT). With RSBT, the increased flexibility beyond conventional high-dose-rate brachytherapy (HDR-BT) due to the partially shielded radiation source has been shown by Adams et al. in 2020 to enable improved urethra sparing (23.1%), enhanced dose escalation (29.9%), or both, with 20 needles without NEEPO-optimized positions. Within this regime of improved dosimetry, we propose in this work that the benefits of RSBT can be maintained while also reducing the number of needles needed for the delivery. The goal of NEEPO is to provide the capability to further increase the dosimetric benefit of RSBT and to minimize the number of needles needed to satisfy a dosimetric goal. Methods: The NEEPO algorithm generates a needle pool for a given patient and then iteratively constructs a subset of needles from the pool based on relative needle importance as determined by total dwell times within needles. The NEEPO algorithm is based on a convex optimization formulation using a quadratic dosimetric penalty function, dwell time regularization by total variation, and a block sparsity regularization term to enable iterative removal of low-importance needles. RSBT treatment plans for 26 patients were generated using single fraction prescriptions with both dose escalation and urethra sparing goals, and compared to baseline HDR-BT treatment plans.