Two-dimensional ZIF-L nanosheets as high performance non-enzymatic glucose sensor

TL;DR

This paper reports the development of 2D Co-ZIF-L nanosheet-based electrochemical biosensors that demonstrate high sensitivity, low detection limit, and stability for non-enzymatic glucose detection, offering a promising new approach in biosensor technology.

Contribution

The study introduces a novel 2D Co-ZIF-L nanosheet structure for non-enzymatic glucose sensing, showing superior electrochemical performance compared to traditional 3D ZIF-67 nanoparticles.

Findings

Higher sensitivity of 769.5 *10$^{-6}$ A mM$^{-1}$ cm$^{-2}$ for Co-ZIF-L nanosheets

Lower detection limit of 90.4 nM achieved

Good selectivity, stability, and reproducibility of the biosensor

Abstract

An effective biosensor based on two-dimensional (2D) Co-ZIF-L nanosheets for sensitive electrochemical non-enzymatic glucose detection is developed, which exhibits high electrocalalytic activities towards glucose due to the ordered porous structure as well as ultrahigh specific surface area. The fabricated Co-ZIF-L nanosheets electrodes present an outstanding performance with higher sensitivity of 769.5 *10$^{-6}$ A mM$^{-1}$ cm$^{-2}$ and lower detect limit of 90.4 nM, while the constructed 3D ZIF-67 nanoparticles electrodes show a weaker sensitivity of 697.4 *10$^{-6}$ A mM$^{-1}$ cm$^{-2}$ and a limited detection range from 2 *10$^{-6}$ M to 414 *10$^{-6}$ M. Furthermore, the Co-ZIF-L based non-enzymatic glucose biosensors possess an acceptable selectivity, long-term stability as well as reproducibility. This work may offer a new approach to develop 2D ZIF nanosheets as a potential candidate in electrochemical biosensors.