Flux limitation mechanisms arising in multiscale modelling of cancer invasion

TL;DR

This paper reviews flux-limited diffusion and taxis models in cancer invasion, highlighting their ability to control propagation speeds and their derivation from multiscale kinetic equations.

Contribution

It provides a comprehensive overview of flux limitation mechanisms in multiscale cancer invasion models, emphasizing their properties and construction methods.

Findings

Flux limitation controls propagation speeds in cancer invasion models.

Models derived from kinetic transport equations ensure realistic cell migration dynamics.

Flux-limited models prevent unnaturally rapid tumor spread.

Abstract

Tumour invasion is an essential stage of cancer progression. Its main drivers are diffusion and taxis, a directed movement along the gradient of a stimulus. Here we review models with flux limited diffusion and/or taxis which have applications in modelling of cell migration, particularly in cancer. Flux limitation ensures control upon propagation speeds, precluding unnaturally quick spread which is typical for traditional parabolic equations. We recall the main properties of models with flux limitation effects and discuss ways to construct them, concentrating on multiscale derivations from kinetic transport equations.