The evolutionary epidemiology of pathogens during vaccination campaigns
Troy Day, David A. Kennedy, Andrew F. Read, Sylvain Gandon
TL;DR
This paper reviews how large-scale vaccination campaigns influence pathogen evolution, drawing on existing research to predict future SARS-CoV-2 evolutionary trends.
Contribution
It synthesizes current knowledge on pathogen evolution during vaccination and applies insights to anticipate SARS-CoV-2's future evolution.
Findings
Vaccination can drive pathogen evolution towards immune escape.
Existing research on other pathogens informs SARS-CoV-2 evolution predictions.
Understanding evolutionary responses can improve vaccination strategies.
Abstract
With the unprecedented global vaccination campaign against SARS-CoV-2 attention has now turned to the potential impact of this large-scale intervention on the evolution of the virus. In this perspective we summarize what is currently known about evolution in the context of vaccination from research on other pathogen species, with an eye towards the future evolution of SARS-CoV-2.
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Taxonomy
TopicsSARS-CoV-2 and COVID-19 Research · Zoonotic diseases and public health · Viral gastroenteritis research and epidemiology