Shear-driven solidification and nonlinear elasticity in epithelial tissues

TL;DR

This paper investigates how shear stresses induce solidification and nonlinear elasticity in epithelial tissues using a computational model, revealing a shear-driven rigidity transition and nonlinear stiffening behavior.

Contribution

It introduces a minimal cell-based model demonstrating shear-driven rigidity and nonlinear elasticity in tissues, supported by a mean-field theoretical framework.

Findings

Tissue acquires rigidity above a critical shear strain.

Tissue exhibits linear response at small strains and nonlinear stiffening at larger strains.

Shear-driven rigidity is explained by a critical scaling near a liquid-solid transition.

Abstract

Biological processes, from morphogenesis to tumor invasion, spontaneously generate shear stresses inside living tissue. The mechanisms that govern the transmission of mechanical forces in epithelia and the collective response of the tissue to bulk shear deformations remain, however, poorly understood. Using a minimal cell-based computational model, we investigate the constitutive relation of confluent tissues under simple shear deformation. We show that an initially undeformed fluidlike tissue acquires finite rigidity above a critical applied strain. This is akin to the shear-driven rigidity observed in other soft matter systems. Interestingly, shear-driven rigidity can be understood by a critical scaling analysis in the vicinity of the second order critical point that governs the liquid-solid transition of the undeformed system. We further show that a solidlike tissue responds linearly only to small strains and but then switches to a nonlinear response at larger stains, with substantial stiffening. Finally, we propose a mean-field formulation for cells under shear that offers a simple physical explanation of shear-driven rigidity and nonlinear response in a tissue.