Seizure pathways and seizure durations can vary independently within individual patients with focal epilepsy

TL;DR

This study investigates the relationship between seizure pathways and durations in focal epilepsy, revealing they can vary independently, which has implications for understanding seizure dynamics and developing targeted treatments.

Contribution

It demonstrates that seizure pathways and durations are modulated by different processes, challenging the assumption that they are directly linked.

Findings

Seizure pathways and durations are often weakly to moderately related within individuals.

Seizures with the same pathway can have different durations, and vice versa.

Seizure durations are not reliable indicators of different pathways.

Abstract

A seizure's electrographic dynamics are characterised by its spatiotemporal evolution, also termed dynamical "pathway" and the time it takes to complete that pathway, which results in the seizure's duration. Both seizure pathways and durations can vary within the same patient, producing seizures with different dynamics, severity, and clinical implications. However, it is unclear whether seizures following the same pathway will have the same duration or if these features can vary independently. We compared within-subject variability in these seizure features using 1) epilepsy monitoring unit intracranial EEG (iEEG) recordings of 31 patients (mean 6.7 days, 16.5 seizures/subject), 2) NeuroVista chronic iEEG recordings of 10 patients (mean 521.2 days, 252.6 seizures/subject), and 3) chronic iEEG recordings of 3 dogs with focal-onset seizures (mean 324.4 days, 62.3 seizures/subject). While the strength of the relationship between seizure pathways and durations was highly subject-specific, in most subjects, changes in seizure pathways were only weakly to moderately associated with differences in seizure durations. The relationship between seizure pathways and durations was weakened by seizures that 1) had a common pathway, but different durations ("elastic pathways"), or 2) had similar durations, but followed different pathways ("duplicate durations"). Even in subjects with distinct populations of short and long seizures, seizure durations were not a reliable indicator of different seizure pathways. These findings suggest that seizure pathways and durations are modulated by different processes. Uncovering such modulators may reveal novel therapeutic targets for reducing seizure duration and severity.