Temperature effect on the cardiac ryanodine receptor gating and conductance: mathematical modelling

TL;DR

This study uses a mathematical electron-conformational model to explain how temperature influences the gating and conductance of cardiac ryanodine receptors, aligning well with experimental data.

Contribution

It introduces a simple EC model with temperature-dependent parameters that accurately describes RyR behavior under different thermal conditions.

Findings

Model reproduces experimental temperature dependence of RyR gating.

Temperature affects RyR conductance and open-close transition rates.

The approach provides a quantitative framework for understanding temperature effects.

Abstract

The temperature effect on the cardiac ryanodine receptor (RyR) function has been studied within the electron-conformational (EC) model. It is shown that simple EC model with the Arrhenius like temperature dependence of "internal" and "external" frictions and a specific thermosensitivity of the tunnelling "open - close" transitions can provide both qualitative and quantitative description of the temperature effects for isolated RyRs. The potential of the model was illustrated by explaining the experimental data on the temperature dependence of sheep's isolated cardiac RyR gating and conductance (R. Sitsapesan et al., J Physiol 434, 469 (1991)).