Strength, corrosion resistance and cellular response of interfaces in bioresorbable poly-lactic acid/Mg fiber composites for orthopedic applications

TL;DR

This study investigates the interface strength, corrosion resistance, and cellular response of poly-lactic acid/Mg fiber composites, highlighting the impact of fiber degradation on mechanical properties and biocompatibility for orthopedic use.

Contribution

It provides new insights into how fiber corrosion affects interface strength and cellular response, emphasizing the need for surface modifications to improve biomedical performance.

Findings

Interface shear strength decreases after immersion in simulated body fluid.

Corrosion leads to fiber expansion and matrix cracking, facilitating further degradation.

Early Mg fiber degradation impairs pre-osteoblast proliferation near fibers.

Abstract

The shear strength and the corrosion resistance of the fiber/matrix interface after immersion in simulated body fluid was studied in poly-lactic acid/Mg fiber composites. The shear strength of the interface was measured by means of push-out tests in thin slices of the composite perpendicular to the fibers. It was found that the interface strength dropped from 15.2 \pm 1.4 MPa to 7.8 \pm 3.7 MPa after the composite was immersed in simulated body fluid for 148 hours. The reduction of the interface strength was associated to the fast corrosion of the fibers as water diffused to the interface through the polymer. The expansion of the fibers due to the formation of corrosion products was enough to promote radial cracks in the polymer matrix which facilitate the ingress of water and the development of corrosion pitting in the fibers. Moreover, cell culture testing on the material showed that early degradation of the Mg fibers affected the proliferation of pre-osteoblasts near the Mg fibers due to the local changes in the environment produced by the fiber corrosion. Thus, surface modification of Mg fibers to delay degradation seems to be a critical point for further development of Mg/PLA composites for biomedical applications.