The Organization of Chaos into a Molecular Trap that Supervises Ligand-Interaction, Selection and Steric Guidance Similar to Events in Black Holes

TL;DR

This study proposes a novel model where allostery involves entropy transfer within a molecular trap that guides ligand interactions, inspired by black hole physics, revealing complex multi-scale energetic and structural mechanisms.

Contribution

It introduces a new conceptual framework linking chaos, entropy, and resonance in molecular traps that regulate ligand binding and selection, inspired by black hole phenomena.

Findings

Ligand binding occurs via steric guidance within a multi-dimensional trap.

Molecular entanglement arises from organized white noise emitted by residue motion.

The trap's physics involve chaotic, harmonic, and electromagnetic field gradients.

Abstract

In the current study, we demonstrated that allostery transpires by entropy transfers across time-spatial scales that actualize the conception of a molecular trap that supervises ligand interaction, selection, and migration into the amphipathic groove of the 14-3-3 {\zeta} docking protein. Ligand binding transpires by steric guidance down a multi-dimensional trap constituted of superimposed chaotic, harmonic, and electromagnetic field gradients. The individual traps exist in discrete domains governed by disparate physics interconnected by their resonance states and are subjective to damping. Notably, the highly structured molecular entanglement was genesis by the organization of white noise emitted by the anarchic motion of residues that comprised many of the features of black holes.