Analysis of the Effect of Atherosclerosis with the Changes of Hematocrit: A Computational Study on the Hemodynamics of Carotid Artery

TL;DR

This study uses computational fluid dynamics to analyze how changes in hematocrit levels affect blood flow and wall stress in carotid arteries, providing insights into atherosclerosis progression.

Contribution

It develops a 2D finite volume model to examine the impact of hematocrit variations on hemodynamics in atherosclerotic carotid arteries, which is a novel computational approach.

Findings

Hematocrit levels significantly influence wall shear stress.

Velocity and pressure gradients vary with atherosclerosis stages.

Model can help identify atherosclerosis development stages.

Abstract

Atherosclerosis is a state wherein plaque (fat, cholesterol, and different substances) develops inside the veins that in the end prompts carotid artery stenosis which is a phase of narrowing in the huge courses situated on either side of the neck that convey blood to the brain, face, and head. Carotid stenosis is regularly connected with perpetual injury of an aspect of the brain (strokes) because of loss of its blood flexibly. For instance, ischemia generally brings about serious handicap or demise. Hematocrit or pressed cell volume (PCV) is the volume of red blood corpuscles according to that of entire blood. The reason for our exploration is to carry out a Computational Fluid Dynamics (CFD) investigation of blood stream with the rate changes of hematocrit to examine the hemodynamic and physiological conduct of atherosclerosis. Our examination a developed 2D calculation model that has been investigated utilizing Finite volume technique (FVM) for interesting phases of atherosclerosis. The point of this investigation is to investigate the social bits of knowledge into the velocity slope, wall shear stress, and pressure gradient of carotid corridor under various rates of hematocrit and various phases of atherosclerosis. The investigation introduced convincing distinction in these boundaries which can be utilized to recognize the atherosclerosis development.