BICNet: A Bayesian Approach for Estimating Task Effects on Intrinsic Connectivity Networks in fMRI Data

TL;DR

This paper introduces BICNet, a Bayesian model that identifies intrinsic brain networks and measures task effects on their dynamics using combined resting-state and task fMRI data, improving understanding of brain connectivity.

Contribution

BICNet is a novel Bayesian framework that jointly identifies ICNs and quantifies task-related effects, outperforming ICA by automatically selecting features and modeling state differences.

Findings

Identified language-related ICNs in HCP data

Quantified differences in ICN amplitudes across rest and task states

Demonstrated robustness in joint modeling of rfMRI and tfMRI

Abstract

Intrinsic connectivity networks (ICNs) are specific dynamic functional brain networks that are consistently found under various conditions including rest and task. Studies have shown that some stimuli actually activate intrinsic connectivity through either suppression, excitation, moderation or modification. Nevertheless, the structure of ICNs and task-related effects on ICNs are not yet fully understood. In this paper, we propose a Bayesian Intrinsic Connectivity Network (BICNet) model to identify the ICNs and quantify the task-related effects on the ICN dynamics. Using an extended Bayesian dynamic sparse latent factor model, the proposed BICNet has the following advantages: (1) it simultaneously identifies the individual ICNs and group-level ICN spatial maps; (2) it robustly identifies ICNs by jointly modeling resting-state functional magnetic resonance imaging (rfMRI) and task-related functional magnetic resonance imaging (tfMRI); (3) compared to independent component analysis (ICA)-based methods, it can quantify the difference of ICNs amplitudes across different states; (4) it automatically performs feature selection through the sparsity of the ICNs rather than ad-hoc thresholding. The proposed BICNet was applied to the rfMRI and language tfMRI data from the Human Connectome Project (HCP) and the analysis identified several ICNs related to distinct language processing functions.