Improving SABRE hyperpolarization with highly non-intuitive pulse sequences: moving beyond avoided crossings to describe dynamics

TL;DR

This paper reveals that moving beyond traditional avoided crossing-based models and employing non-intuitive pulse sequences can significantly enhance SABRE hyperpolarization, supported by accurate simulations and experimental validation.

Contribution

It introduces a new theoretical framework that explains unexpected SABRE dynamics and designs novel pulse sequences that outperform existing methods.

Findings

Significant signal enhancements achieved experimentally.

Accurate simulations reveal complex, rich SABRE dynamics.

Non-intuitive pulse sequences outperform traditional approaches.

Abstract

Signal Amplification By Reversible Exchange (SABRE) creates hyperpolarization (large spin magnetization) using a transition metal catalyst and parahydrogen, addressing the sensitivity limitations of magnetic resonance. SABRE and its heteronuclear variant X-SABRE are simple, fast and general, but to date have not produced polarization levels as large as more established methods. We show here that inaccuracies in the theoretical framework for these applications, which focuses on avoided crossings (also called level anti-crossings or LACs) steer current SABRE and X-SABRE experiments away from optimal solutions. Accurate simulations show astonishingly rich and unexpected dynamics in SABRE/X-SABRE, which we explain with a combination of perturbation theory and average Hamiltonian approaches. This theoretical picture predicts simple pulse sequences with field values far from LACs (both instantaneously and on average), using different terms in the effective Hamiltonian to strategically control evolution and improve polarization transfer. Significant signal enhancements under such highly non-intuitive conditions are verified experimentally.