Information-theoretic characterization of the complete genotype-phenotype map of a complex pre-biotic world

TL;DR

This paper uses information theory to analyze a vast genotype-phenotype map, revealing how biological information is robustly encoded and compressed across over 5 trillion sequences, advancing understanding of pre-biotic molecular information encoding.

Contribution

It provides the first comprehensive information-theoretic analysis of a complete genotype-phenotype map with over 5 trillion sequences, uncovering encoding patterns.

Findings

Revealed robust and compressed genetic encodings

Analyzed the largest complete genotype-phenotype map to date

Demonstrated the utility of information theory in biological sequence analysis

Abstract

How information is encoded in bio-molecular sequences is difficult to quantify since such an analysis usually requires sampling an exponentially large genetic space. Here we show how information theory reveals both robust and compressed encodings in the largest complete genotype-phenotype map (over 5 trillion sequences) obtained to date.