Choroidal vasculature imaging with laser Doppler holography

TL;DR

This paper demonstrates that laser Doppler holography can effectively image and differentiate choroidal vessels in humans, offering high contrast and resolution comparable to existing imaging techniques, thus advancing understanding of choroidal vascular flow.

Contribution

The study introduces laser Doppler holography as a novel method for high-resolution, high-contrast imaging of choroidal vasculature and flow differentiation in humans.

Findings

Provides high contrast imaging of choroidal vessels

Achieves spatial resolution comparable to established methods

Enables differentiation of arteries and veins in the choroid

Abstract

The choroid is a highly vascularized tissues supplying the retinal pigment epithelium and photoreceptors. Its implication in retinal diseases is gaining increasing interest. However, investigating the anatomy and flow of the choroid remains challenging. Here we show that laser Doppler holography provides high contrast imaging of choroidal vessels in humans, with a spatial resolution comparable to state of the art indocyanine green angiography and optical coherence tomography. Additionally, laser Doppler holography contributes to sort out choroidal arteries and veins by using a power Doppler spectral analysis. We thus demonstrate the potential of laser Doppler holography to improve our understanding of the anatomy and flow of the choroidal vascular network.