Two hydrodynamic effects allow strongly nonlinear cochlear response with level-independent admittance

TL;DR

This paper reveals how two hydrodynamic effects in cochlear fluid dynamics produce a highly nonlinear, level-independent admittance and stabilize high-gain responses, explaining the cochlear nonlinear response over a wide stimulus range.

Contribution

It introduces an analytical 2-D WKB approach and compares it with 3-D finite element models to demonstrate hydrodynamic effects' role in cochlear nonlinearities.

Findings

Hydrodynamic effects cause stable high-gain cochlear responses.

Level-independent admittance explained by anti-damping OHC forces.

Model comparisons show wide-range nonlinear response simulation.

Abstract

This paper discusses the role of 2-D/3-D cochlear fluid hydrodynamics in the generation of the large nonlinear dynamical range of the basilar membrane (BM) and pressure response, in the decoupling between cochlear gain and tuning, and in the dynamic stabilization of the high-gain BM response in the peak region. The large and closely correlated dependence on stimulus level of the BM velocity and fluid pressure gain (Dong and Olson, 2013), is consistent with a physiologically-oriented schematization of the outer hair cell (OHC) mechanism if two hydrodynamic effects are accounted for: amplification of the differential pressure associated with a focusing phenomenon, and viscous damping at the BM-fluid interface. The predictions of the analytical 2-D WKB approach are compared to solutions of a 3-D finite element model, showing that these hydrodynamic phenomena yield stable high-gain response in the peak region and a smooth transition among models with different effectiveness of the active mechanism, mimicking the cochlear nonlinear response over a wide stimulus level range. This study explains how an effectively anti-damping nonlinear OHC force may yield large BM and pressure dynamical ranges along with an almost level-independent admittance.