Phase Entrainment by Periodic Stimuli In Silico: A Quantitative Study

TL;DR

This study uses a biologically inspired neural network model to quantitatively analyze how periodic visual stimuli can entrain brain oscillations, providing insights into therapeutic applications for neurological disorders.

Contribution

It demonstrates the use of in silico models to understand neuronal phase entrainment and validates the approach with experimental data on brain oscillations.

Findings

Phase synchronization disappears with jitter in input intervals.

Entrainment is demonstrated through phase locking and entropy measures.

Model predictions align with experimental observations of brain responses.

Abstract

We present a quantitative study of phase entrainment by periodic visual stimuli in a biologically inspired neural network. The objective is to understand the neuronal population dynamics that underlie phase entrainment of brain oscillations by external stimuli, which is used for therapeutic treatment in neurological disorders, for example in Parkinsonian tremor. Yet, the neuronal dynamics underpinning such entrainment is not fully understood. Rhythmic sensory stimulation is one way of studying phase synchronization in the brain. A recent experimental study has reported phase entrainment of brain oscillations during steady state visually evoked potentials (SSVEP), which are scalp electroencephalogram corresponding to periodic stimuli. We have simulated SSVEP-like signals corresponding to periodic pulse input to our in silico model. We have used phase locking values, normalised Shannon entropy and conditional probability as synchronisation indices to show phase synchrony in the neuronal populations. Our experiment demonstrates that the phase synchronisation disappears with jitter in the input inter-pulse intervals, and this would not be the case if the output signal were to be the superposition of the responses to the different input signals. Thus, the phase synchronisation implies entrainment of the network response by the periodic input. Overall, our study shows the plausibility of using biologically inspired in silico models, validated by experimental works, to understand and make testable predictions on brain entrainment as a therapeutic treatment in specific neurological disorders.