Optimal control of an HIV model with a trilinear antibody growth function

TL;DR

This paper introduces a new HIV model incorporating a trilinear antibody growth function dependent on virus, antibodies, and uninfected cells, and explores optimal control strategies for treatments.

Contribution

It presents a novel HIV model with a trilinear antibody growth function and analyzes optimal control strategies for different treatment objectives.

Findings

Positivity and boundedness of solutions established

Local stability of disease-free and infected states characterized

Numerical simulations demonstrate treatment effectiveness

Abstract

We propose and study a new mathematical model of the human immunodeficiency virus (HIV). The main novelty is to consider that the antibody growth depends not only on the virus and on the antibodies concentration but also on the uninfected cells concentration. The model consists of five nonlinear differential equations describing the evolution of the uninfected cells, the infected ones, the free viruses, and the adaptive immunity. The adaptive immune response is represented by the cytotoxic T-lymphocytes (CTL) cells and the antibodies with the growth function supposed to be trilinear. The model includes two kinds of treatments. The objective of the first one is to reduce the number of infected cells, while the aim of the second is to block free viruses. Firstly, the positivity and the boundedness of solutions are established. After that, the local stability of the disease free steady state and the infection steady states are characterized. Next, an optimal control problem is posed and investigated. Finally, numerical simulations are performed in order to show the behavior of solutions and the effectiveness of the two incorporated treatments via an efficient optimal control strategy.