Evaluation of blood coagulation by optical vortex tracking

TL;DR

This paper presents a novel optical vortex tracking method using laser speckle analysis to monitor blood coagulation dynamics in real-time, showing strong correlation with traditional thrombelastography.

Contribution

It introduces an innovative optical approach for coagulation detection based on optical vortex motion analysis, offering potential for self-testing and rapid assessment.

Findings

Optical vortex motion correlates with coagulation parameters.

The method matches thrombelastography results.

Enables real-time coagulation monitoring.

Abstract

We investigated a new optical approach for the detection of the coagulation dynamic process by means of the information on the optical vortex. In our study, laser speckle was captured using a high-speed CMOS camera, and the statistical information of the optical vortex characterized the change in coagulation properties with time. Similar to the scattering particles, the motion of the optical vortex is restricted during coagulation, as a result, the whole process of coagulation can be detected by calculating the mean square displacement(MSD) of the optical vortex. The results demonstrate a close correlation between coagulation parameters measured using the optical vortex method and thrombelastography(TEG), creating a powerful opportunity for self-testing and real-time detection of coagulation.