Integrative Wireless Device for Remote Continuous Blood Biomarker Monitoring

TL;DR

This paper introduces a novel wireless device capable of real-time, continuous monitoring of drug levels in unprocessed blood, enabling remote healthcare and precision medicine at home.

Contribution

It presents an integrative, buffer-free wireless sensor that measures drug concentrations in unprocessed blood in real time, demonstrated with doxorubicin in live animals.

Findings

Successfully measured drug levels in live animal blood over 8 hours.

Achieved sub-minute temporal resolution in monitoring drug dynamics.

Enabled remote, continuous blood biomarker monitoring for precision medicine.

Abstract

To perform precision medicine in realtime at home, a device capable of long distance continuously monitoring target biomolecules in unprocessed blood under dynamic situations is essential. In this study, an integrative buffer free wireless device is developed to measure drug concentrations in patients blood in real time for remote clinical healthcare. To demonstrate its capability, the drug molecules (i.e., small molecule drug doxorubicin, DOX) are continuously measured in the unprocessed whole blood of live animals (e.g., rats). The dynamic changes of drug concentrations with sub minute temporal resolution are recorded for an extended period of time (8 hours). As an advance in remote diagnosis, this device would benefit the public by enabling long-distance precision medicine to prevent pandemics in advance.