Feedback-controlled microbubble generator producing one million monodisperse bubbles per second
Benjamin van Elburg, Gonzalo Collado Lara, Gert-Wim Bruggert, Tim, Segers, Michel Versluis, Guillaume Lajoinie

TL;DR
This paper introduces a feedback-controlled microbubble generator on a chip that produces up to one million monodisperse bubbles per second with precise size and rate control, advancing ultrasound contrast agent technology.
Contribution
It presents a novel lab-on-a-chip device with real-time optical measurement and feedback control for high-rate, monodisperse microbubble production, enabling better control for medical applications.
Findings
Achieved production rates up to 10^6 bubbles/sec.
Controlled bubble sizes from 2.5 to 20 μm.
Stabilized bubbles at roughly half initial size without losing monodispersity.
Abstract
Monodisperse lipid-coated microbubbles are a promising route to unlock the full potential of ultrasound contrast agents for medical diagnosis and therapy. Here, we present a stand-alone lab-on-a-chip instrument that allows microbubbles to be formed with high monodispersity at high production rates. Key to maintaining a long-term stable, controlled, and safe operation of the microfluidic device with full control over the output size distribution is an optical transmission based measurement technique that provides real-time information on production rate and bubble size. We feed the data into a feedback loop and demonstrate that this system can control the on-chip bubble radius (2.5 to 20 m) and the production rate up to bubbles/s. The freshly formed phospholipid-coated bubbles stabilize after their formation to a size approximately two times smaller than their initial on-chip…
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