Effect of Strain Rate on Single Tau, Dimerized Tau and Tau-Microtubule Interface: a Molecular Dynamics Simulation Study

TL;DR

This study uses molecular dynamics simulations to explore how high strain rates affect the mechanical behavior of tau proteins and their interaction with microtubules, providing insights into their structural stability.

Contribution

It introduces a detailed molecular dynamics approach to analyze the strain rate effects on tau proteins and tau-microtubule interfaces, which was not extensively studied before.

Findings

High strain rates significantly alter tau protein stability.

Dimerized tau shows different mechanical responses compared to single tau.

Tau-microtubule interface strength varies with strain rate.

Abstract

In this study, the mechanical behavior of single tau, dimerized tau, and tau-microtubule interface subjected to high strain rate is investigated by molecular dynamics simulation.