Is it who you are or where you are? Accounting for compositional differences in cross-site treatment variation
Benjamin Lu, Eli Ben-Michael, Avi Feller, Luke Miratrix

TL;DR
This paper introduces a method to distinguish between compositional and contextual treatment effect variations in multisite trials by using covariate balancing weights, enabling better understanding of site-specific effects.
Contribution
The paper develops a novel framework for effect transportation in multisite trials using approximate balancing weights to isolate contextual effects.
Findings
Effective covariate balancing achieved in simulations
Method successfully applied to welfare-to-work trial data
Available implementation in the balancer R package
Abstract
Multisite trials, in which treatment is randomized separately in multiple sites, offer a unique opportunity to disentangle treatment effect variation due to "compositional" differences in the distributions of unit-level features from variation due to "contextual" differences in site-level features. In particular, if we can re-weight (or "transport") each site to have a common distribution of unit-level covariates, the remaining effect variation captures contextual differences across sites. In this paper, we develop a framework for transporting effects in multisite trials using approximate balancing weights, where the weights are chosen to directly optimize unit-level covariate balance between each site and the target distribution. We first develop our approach for the general setting of transporting the effect of a single-site trial. We then extend our method to multisite trials, assess…
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Taxonomy
TopicsAdvanced Causal Inference Techniques · Health Systems, Economic Evaluations, Quality of Life · Economic and Environmental Valuation
