Challenges in systematic reviews and meta-analyses of mediation analyses
Tat-Thang Vo, Stijn Vansteelandt

TL;DR
This paper discusses the current challenges faced in conducting systematic reviews and meta-analyses of mediation studies and proposes practical solutions to improve the methodology.
Contribution
It identifies key methodological challenges in mediation reviews and offers strategies to address them, advancing the field's review practices.
Findings
Highlighting methodological challenges in mediation reviews
Proposing practical solutions for review improvements
Encouraging standardized approaches in mediation meta-analyses
Abstract
Systematic reviews and meta-analyses of mediation studies are increasingly being implemented in practice. Nonetheless, the methodology for conducting such review and analysis is still in a development phase, with much room for improvement. In this paper, we highlight and discuss challenges that investigators face in mediation systematic reviews and meta-analyses, then propose ways of accommodating these in practice.
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