High-precision Quantum Transmitometry of DNA and Methylene-Blue using a Frequency-Entangled Twin-Photon Beam in Type-I SPDC

TL;DR

This paper demonstrates high-precision quantum transmittometry using frequency-entangled twin-photons to measure DNA, Methylene-Blue, and multilayer films with unprecedented accuracy, enabling detection of very dilute samples and potential biomedical applications.

Contribution

The study introduces a quantum measurement technique using coincidence-count of entangled photons for highly accurate transmittance measurement, surpassing classical methods in sensitivity and reliability.

Findings

Achieved 0.01% measurement accuracy with quantum correlation.

Successfully distinguished very dilute DNA and MB solutions.

Potential application in non-invasive quantum biomedical diagnostics.

Abstract

Using the coincidence-count (CC) measurement of the generated frequency-entangled twin-photons beam (TWB) via the process of type-I spontaneous parametric-down conversion (SPDC) in BBO nonlinear crystal (NLC), we have precisely measured the transmittance of very diluted Rabbit- and Human-DNA, Methylene-Blue (MB), as a disinfectant, and thin-film multilayer at near IR wavelength 810nm with an accuracy in order of $\% 0.01 $ due to the quantum correlation, while accuracy of classical-like measurement, single-count (SC), is in order of $\% 0.1 $ in our setup. Moreover, using quantum measurement of the transmittance, the different types of DNA with the same concentration, and also very diluted (in order of pg/$ \mu $l) different concentrations of DNA and MB solutions are distinguished and detected with high-reliability. Interestingly, in case of Human-DNA samples in contrast to our classical-like measurement we could precisely detect and distinguish two very diluted concentrations $ 0.01\rm ng/\mu l $ and $ 0.1\rm ng/\mu l $ with high reliability while commercial standard spectrometer device of our DNA-manufacturer never could detect and distinguish them. Surprisingly, measurement on the thin-film multilayer illustrates that the introduced method in this work might be performed to cancer/brain tissues or Stem cells for cancer therapy, and may hopefully open a pave and platform for non-invasive quantum diagnosis in future.