Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection

TL;DR

This study introduces mesoporous bioactive glasses with molecular gates for targeted drug delivery, showing potential for treating bone tumors and infections through innovative nanodevices tested in vitro.

Contribution

Development of ATP and { extepsilon}-poly-L-lysine gated nanodevices on mesoporous bioactive glasses for controlled drug release in bone therapy applications.

Findings

Successful implementation of molecular gates with ATP and { extepsilon}-poly-L-lysine.

Effective drug delivery demonstrated with antibiotics and anticancer drugs.

Promising bioactivity and in vitro results for bone treatment applications.

Abstract

Silica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties. Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. In this work, we have developed innovative nanodevices based on the implementation of adenosine triphosphate (ATP) and {\epsilon}-poly-L-lysine molecular gates using a mesoporous bioglass as an inorganic support. The systems have been previously proved to work properly with a fluorescence probe and subsequently with an antibiotic (levofloxacin) and an antitumoral drug (doxorubicin). The bioactivity of the prepared materials has also been tested, giving promising results. Finally, in vitro cell culture studies have been carried out; demonstrating that this gated devices can provide useful approaches for bone cancer and bone infection treatments.