Closed testing procedures for treatment-versus-control comparisons and multiple correlated endpoint

TL;DR

This paper compares closed testing procedures and max(maxT) tests for analyzing multiple correlated endpoints in small-arm randomized clinical trials, focusing on their power and error control.

Contribution

It introduces a comparison of closed testing and max(maxT) procedures specifically for multiple correlated endpoints in small randomized trials.

Findings

Max(maxT) tests show competitive power compared to closed testing.

The study evaluates any-pairs, all-pairs, and individual power.

Simulation results guide test selection for correlated endpoints.

Abstract

Preferably in two- or three-arm randomized clinical trials, a few (2,3) correlated multiple primary endpoints are considered. In addition to the closed testing principle based on different global tests, two max(maxT) tests are compared with respect to any-pairs, all-pairs and individual power in a simulation study.